DNA REPLICATION

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. In a cell, DNA replication begins at specific locations in the genome, called "origins". Unwinding of DNA at the origin, and synthesis of new strands, forms a replication fork. In addition to DNA polymerase, the enzyme that synthesizes the new DNA by adding nucleotides matched to the template strand, a number of other proteins are associated with the fork and assist in the initiation and continuation of DNA synthesis.

Download a PDF file (To save Right Click and "Save")
On "Roles of Nuclear Structure in DNA Replication" http://dnareplication.cshl.edu/content/free/chapters/04_laskey.pdf

For Notes on Bacterial Replication: (Right Click and "Save")
http://www.sjsu.edu/depts/Biology/facultystaff/soto/DNAreplication.pdf

Click below to see an animation on DNA replication and also make a point to see the quiz in it:
http://www.bioteach.ubc.ca/TeachingResources/MolecularBiology/DNAReplication.swf

Click for a You Tube Video:
http://in.youtube.com/watch?v=teV62zrm2P0

Notes on "An expanded view of bacterial DNA replication" (Right Click and "Save Taget As")
http://www.pnas.org/cgi/reprint/99/12/8342.pdf

Notes on "A Boradening View of Recombinational DNA Repair in Bacteria" (Right Click and "Save ")
http://www.genestocellsonline.org/cgi/reprint/3/2/65.pdf

Notes on "VIRAL DNA POLYMERASES" (Right Click and "Save ")
http://dnareplication.cshl.edu/content/free/chapters/16_coen.pdf

Details about "EUKARYOTIC DNA POLYMERASES" (Right Click and "Save")
http://labs.fhcrc.org/stoddard/MCB_542/hubscher_etal_2002.pdf

Details about "BACTERIAL DNA POLYMERASES" http://www.mun.ca/biochem/courses/3107/Topics/DNA_polymerases.html

Details about "DNA REPLICATION AND ENZYMOLOGY OF DNA REPLICATION" (Right Click and "Save ")
http://www.rocw.raifoundation.org/biotechnology/MScBioinformatics/geneticengineeringvirologyandvectordesign/lecture-notes/lecture-04.pdf